Glossary entry (derived from question below)
German term or phrase:
resistenzstabil
English translation:
no genotypic resistance//no drug resistance
Added to glossary by
Christine Lam
Aug 14, 2012 14:50
11 yrs ago
German term
resistenzstabil
German to English
Medical
Medical: Pharmaceuticals
Eine durch die Chemotherapie induzierte Reaktivierung einer
Hepatitis B ist mit einer hohen Letalität assoziiert, kann
in Einzelfällen aber sehr einfach und erfolgreich durch potente
und resistenzstabile Nukleosidanaloga therapiert werden.
Einfach nur "resistant"?
VDiV
Hepatitis B ist mit einer hohen Letalität assoziiert, kann
in Einzelfällen aber sehr einfach und erfolgreich durch potente
und resistenzstabile Nukleosidanaloga therapiert werden.
Einfach nur "resistant"?
VDiV
Proposed translations
29 mins
Selected
no genotypic resistance//no drug resistance
http://www.eurekalert.org/pub_releases/2011-04/w-hbv042711.p...
It means that hep B strains are not resistant to these analogues (nucleoside analogs tend to be associated with relatively high incidence of resistance)
It means that hep B strains are not resistant to these analogues (nucleoside analogs tend to be associated with relatively high incidence of resistance)
4 KudoZ points awarded for this answer.
Comment: "thank you all for your help!"
24 mins
Carmen Lawrence
Greece
Greece
Native in English
Works in field
Greece
Professional, fast, dependable
Native in: English (Variants: UK, US, British) 
Works in: German to English, Dutch to English, English, and 1 more.
Related KudoZ points
:
8
stably resistant
sustained resistance rather than sporadic or short-term resistance
Reference:
Peer comment(s):
| neutral |
Lirka
: but--if these strains are resistant to nucleoside analog(ue)s, why is therapy described as 'einfach und erfolgreich'?; doesn't make sense to me
6 mins
|
1 hr
Marga Shaw
United Kingdom
United Kingdom
Native in German
Specializes in field
United Kingdom
Language matters
Native in: German (Variants: Austrian, Germany, Swiss)
Works in: English to German, German to English
Related KudoZ points
:
154
with to date the lowest rate of resistance/no resistance
.. can be successfully treated with potent nucleoside analogues with to date the lowest rate of resistance/with no resistance
http://www.ccjm.org/content/76/Suppl_3/S14.long
The goal of antiviral therapy for chronic hepatitis B (HBV) with oral nucleoside or nucleotide analogues is to ensure sustained suppression of HBV virologic activity as measured by quantitation of HBV DNA and ultimately, to prevent cirrhosis, hepatic failure, and hepatocellular cancer[1]. Unfortunately, prolonged therapy with these agents can result in the emergence of antiviral resistance. The development of resistance depends on a number of variables: pre-treatment HBV DNA levels, rapidity of viral suppression (often correlated with potency of agent), degree of genetic barrier to resistance of agent (threshold probability the virus will mutate under selective pressure from the drug), duration of treatment, and prior exposure to oral antiviral therapy[2].
http://depts.washington.edu/hepstudy/hepB/mgmt/treatment/dis...
http://www.emedicinehealth.com/hepatitis_b_treatment/page5_e...
-1
2 hrs
(nucleoside analogues) not susceptible to resistance
My take...
Apologies, no time to provide accurate URLs - off to Scotland within hours... ;-))
Apologies, no time to provide accurate URLs - off to Scotland within hours... ;-))
Peer comment(s):
| disagree |
Harald Moelzer (medical-translator)
: Nukleosidanaloga/NRTI führen zwar seltener zu Resistenzen, es kommt aber häufig zu Kreuzresistenzen - man kann also auf keinen Fall behaupten, sie seien nicht anfällig für Resistenzen...
5 days
|
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