Nov 17, 2011 18:20
12 yrs ago
German term

DIRE

German to English Medical Medical (general) Laboratory testing
This is in a laboratory report in a German medical report:

"LDL CHOLESTERIN DIRE"

I did some googling and found several references to this test in German, but no explanation of what the letters mean. I found no references to DIRE in the English language google (Hard to search, since the English word "dire" comes up).

Does anyone know what the DIRE test is and what it is in English?

Thanks,

Stephen
Proposed translations (English)
3 +4 direct

Discussion

Siegfried Armbruster Nov 17, 2011:
DIRE = DIREKT LDL-Cholesterin: Bestimmung direkt oder mit der Friedewald-Formel.
philgoddard Nov 17, 2011:
Maybe it means "dire" :-)

Proposed translations

+4
7 mins
Selected

direct

I think it might stand for direkt (direct), see info below:

Why accept a calculated LDL result now that an accurate, measured, Direct LDL test is available?

Given the importance of LDL cholesterol as a focus of coronary heart disease (CHD) risk reduction, it is an irony of contemporary medicine generally not recognized by clinicians that LDL cholesterol values are based on an estimate.

Many laboratories currently use the equation known as the Friedewald Formula to estimate LDL cholesterol concentration. This formula estimates LDL concentration by subtracting the cholesterol associated with other classes of lipoprotiens from total cholesterol. The limitations of the Friedewald estimate are well documented but not widely appreciated.

When LDL cholesterol measurements are ordered, most clinical laboratories default to estimating LDL cholesterol values by means of the Friedewald formula.

Problems associated with the Friedewald (calculated) Method:

The Friedewald Formula requires multiple steps, with each step adding a potential source for error.
The method is innaccurate as triglyceride levels increase.
Patients must fast before the test is administered in order to avoid a triglyceride bias.
http://www.directldl.com/healthcare/dldl_healthcare_calcldl....

http://labtestsonline.org/understanding/analytes/dldl/tab/gl...
Peer comment(s):

agree Gisela Greenlee
6 mins
Thank you, Gisela!
agree Siegfried Armbruster
8 mins
Thank you, Siegfried!
agree Sven Petersson
35 mins
Thank you, Sven!
agree Harald Moelzer (medical-translator)
4 days
Thank you, Harald!
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4 KudoZ points awarded for this answer. Comment: "Thanks, Patricia!"
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