Glossary entry (derived from question below)
Italian term or phrase:
topo per oz
English translation:
oral LD50 in mice: 10,000 mg/kg
Added to glossary by
Ida DeFlaviis
Aug 30, 2002 12:16
21 yrs ago
Italian term
topo per oz
Italian to English
Science
Bassa tossicita acuta (DL 50 topo per oz: 10.000 mg/kg
Proposed translations
(English)
5 +3 | oral LD50 in mice: 10,000 mg/kg | Ida DeFlaviis |
5 | os | asynge |
4 -1 | per ounce of mouse body weight | marfus |
2 | DL 50 mouse per oz | M_Falzone |
Proposed translations
+3
32 mins
Selected
oral LD50 in mice: 10,000 mg/kg
I believe the "oz" is "os" in this case which stands for "oral administration". Anyway, see below for the definition of LD50, along with some of the references found on Internet.
What does LD50 mean?
LD stands for "Lethal Dose". LD50 is the amount of a material, given all at once, which causes the death of 50% (one half) of a group of test animals. The LD50 is one way to measure the short-term poisoning potential (acute toxicity) of a material.
Toxicologists can use many kinds of animals but most often testing is done with rats and mice. It is usually expressed as the amount of chemical administered (e.g., milligrams) per 100 grams (or kilogram) of the body weight of the test animal. The LD50 can be found for any route of entry or administration but dermal (applied to the skin) and oral (given by mouth) administration methods are the most common.
http://www.ccohs.ca/oshanswers/chemicals/ld50.html
Other references are:
http://www.sepro.com/horticulture/decree/DcreMSDS.PDF (see page 3 of this document which is a data sheet for a fungicide)
http://www.rxlist.com/cgi/generic/trisulf_od.htm
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Note added at 2002-08-30 13:32:56 (GMT)
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There are close to 6,000 results that refer to the LD50 toxicological evaluation as being \"os\" (orally administered). This is the reason why I think the \"oz\" is a mispelling, along with the fact that the two weight measurements have nothing to do with each other.
What does LD50 mean?
LD stands for "Lethal Dose". LD50 is the amount of a material, given all at once, which causes the death of 50% (one half) of a group of test animals. The LD50 is one way to measure the short-term poisoning potential (acute toxicity) of a material.
Toxicologists can use many kinds of animals but most often testing is done with rats and mice. It is usually expressed as the amount of chemical administered (e.g., milligrams) per 100 grams (or kilogram) of the body weight of the test animal. The LD50 can be found for any route of entry or administration but dermal (applied to the skin) and oral (given by mouth) administration methods are the most common.
http://www.ccohs.ca/oshanswers/chemicals/ld50.html
Other references are:
http://www.sepro.com/horticulture/decree/DcreMSDS.PDF (see page 3 of this document which is a data sheet for a fungicide)
http://www.rxlist.com/cgi/generic/trisulf_od.htm
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Note added at 2002-08-30 13:32:56 (GMT)
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There are close to 6,000 results that refer to the LD50 toxicological evaluation as being \"os\" (orally administered). This is the reason why I think the \"oz\" is a mispelling, along with the fact that the two weight measurements have nothing to do with each other.
4 KudoZ points awarded for this answer.
Comment: "Thanks. Grateful for the references ,evne if I couldn't download/read them! I thought you were all joking at first!
The oz was unclear in the faxed original text and may well have been os. The context was of toxins ingested, which adds further weight to your translatioin."
-1
18 mins
per ounce of mouse body weight
which is of course inconsistent with mg/kg, but this is just how things are in our vale of tears
Peer comment(s):
disagree |
Ida DeFlaviis
: see answer below
55 mins
|
your argument is convincing, i admit
|
28 mins
DL 50 mouse per oz
I think ir refers to the concentration of DL 50 in the mouse body per ounce:
The DL 50 of white venoms from BV was 0.63 µg/20 g mouse (range: 0.45-0.79 µg)
while that of yellow venoms was 2.24 µg/20 g mouse (range: 1.95-2.53 µg). ...
www.cevap.org.br/revistas/jvat197/poste001.htm
The DL 50 of white venoms from BV was 0.63 µg/20 g mouse (range: 0.45-0.79 µg)
while that of yellow venoms was 2.24 µg/20 g mouse (range: 1.95-2.53 µg). ...
www.cevap.org.br/revistas/jvat197/poste001.htm
hope it helps
The DL 50 of white venoms from BV was 0.63 µg/20 g mouse (range: 0.45-0.79 µg)
while that of yellow venoms was 2.24 µg/20 g mouse (range: 1.95-2.53 µg). ...
www.cevap.org.br/revistas/jvat197/poste001.htm
The DL 50 of white venoms from BV was 0.63 µg/20 g mouse (range: 0.45-0.79 µg)
while that of yellow venoms was 2.24 µg/20 g mouse (range: 1.95-2.53 µg). ...
www.cevap.org.br/revistas/jvat197/poste001.htm
hope it helps
1 hr
os
LD = lethal dose
kg = weight of mouse
oz (sic) = oz = oral route
N.B. lethal dose is associated with route of administration, so 10.000 mg/kg may be equalent to let's say 5.125 mg/kg intravenous
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Note added at 2002-08-30 16:02:04 (GMT) Post-grading
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I suspect the dot you have in the Italian is a decimal point; check because mg is milligram and 10,000 mg is 10 Kg. That\'s quite some mouse if it can take ten times it\'s own weight of anything!
kg = weight of mouse
oz (sic) = oz = oral route
N.B. lethal dose is associated with route of administration, so 10.000 mg/kg may be equalent to let's say 5.125 mg/kg intravenous
--------------------------------------------------
Note added at 2002-08-30 16:02:04 (GMT) Post-grading
--------------------------------------------------
I suspect the dot you have in the Italian is a decimal point; check because mg is milligram and 10,000 mg is 10 Kg. That\'s quite some mouse if it can take ten times it\'s own weight of anything!
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