May 27, 2007 08:50
16 yrs ago
14 viewers *
English term
GEKAMON (X)
acute-on-chronic response case
English
Medical
Medical: Pharmaceuticals
побочные явления
There were no breakthrough or acute-on-chronic response case observed.
Can anybody explain this "acute-on-chronic", please? May it deals with acute and chronic hypersensititvity reactions?
Can anybody explain this "acute-on-chronic", please? May it deals with acute and chronic hypersensititvity reactions?
Responses
| 4 +2 | acute-on-chronic response with depot leuprolide |
MMUlr
|
| 3 | acute-on-chronic pain |
Lia Fail (X)
|
| 1 | "exacerbation" |
Alexander Vorobyev
|
| 1 | acute on chronic basis |
Cagdas Karatas
|
Responses
+2
2 hrs
Selected
acute-on-chronic response with depot leuprolide
This is not about systemic hypersensitivity which was part of the safety discussion in Phase I trials - see your quoted sentence above.
Regarding leuprolide / Eligard treatment of patients with advanced prostate cancer, breakthrough and acute-on-chronic response are discussed. These terms have different definitions:
1. breakthrough:
http://www.eligard.com/hcp/prodInfo/prodInfoCVA.asp?varShow=...
--> increase of testosterone level to >50 ng/dL
2. acute-on-chronic:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=...
--> agonistic stimulation of serum testosterone following reinjection (i.e., increase in serum testosterone, but not at a predefined level)
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Note added at 2 hrs (2007-05-27 11:08:56 GMT)
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@GEKAMON, here your Russian KudoZ colleagues should help .... but it was a pleasure to clarify things at least in English ;-)
Regarding leuprolide / Eligard treatment of patients with advanced prostate cancer, breakthrough and acute-on-chronic response are discussed. These terms have different definitions:
1. breakthrough:
http://www.eligard.com/hcp/prodInfo/prodInfoCVA.asp?varShow=...
--> increase of testosterone level to >50 ng/dL
2. acute-on-chronic:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=...
--> agonistic stimulation of serum testosterone following reinjection (i.e., increase in serum testosterone, but not at a predefined level)
--------------------------------------------------
Note added at 2 hrs (2007-05-27 11:08:56 GMT)
--------------------------------------------------
@GEKAMON, here your Russian KudoZ colleagues should help .... but it was a pleasure to clarify things at least in English ;-)
Note from asker:
| You are really a treasure! Thank you! And now I have a headache how to translate in into Russian :( |
Peer comment(s):
| agree |
Alexander Vorobyev
: "Context is everything"!
10 mins
|
|
Thank you, Alexander :-)
|
|
| agree |
Alfa Trans (X)
7 hrs
|
|
Thank you, Marju.
|
4 KudoZ points awarded for this answer.
Comment: "THANKS!!!!!!!!!!!!!!"
9 mins
"exacerbation"
"breakthrough" - a first reaction (while on study treatment),
"acute-on-chronic" - exacerbation of a pre-existing process.
"acute-on-chronic" - exacerbation of a pre-existing process.
Note from asker:
| In my context breakthrough is a sharp increase in testosterone lever following its reduction after administration of the drug. And we may call it exacerbation. "Acute-on chronic" is something different. |
17 mins
acute on chronic basis
a case that has advanced with chronic responses (proving to be a lasting one)
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Note added at 19 mins (2007-05-27 09:10:28 GMT)
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In Turkish they seem to be expressing acute-on-chronic as "acute on chronic (back)ground"
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Note added at 19 mins (2007-05-27 09:10:28 GMT)
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In Turkish they seem to be expressing acute-on-chronic as "acute on chronic (back)ground"
Note from asker:
| Thank you for active discussion of my postings! :) But my text deals with cancer treatment. I am not sure that we may talk about "acute' case of cancer advancing to "chorinc" one. It's possible for infections but not for cancer (IMHO). |
56 mins
acute-on-chronic pain
We really need more context, but pain is an option.
Acute on chronic pain. Acute pain may arise on a background of chronic pain, for example due to .....
http://www.mhra.gov.uk/home/idcplg?IdcService=GET_FILE&dDocN...
Types of Pain
Pain in the veterinary patient can be divided into two general catagories -- acute and chronic pain -- with a third category that combines the two: acute on chronic.
Acute Pain. This is the pain generated by a traumatic or medical event that happens suddenly in an otherwise pain-free patient. Examples of events that can cause acute pain are surgical procedures, automobile accidents and other traumatic accidents, and medical conditions such as inflammation of the pancreas.
Chronic Pain. Chronic pain is often caused by conditions such as arthritis or chronic intervertebral disc disease. This is a very common category of pain in our patients.
Acute on Chronic. Occasionally we will see patients that have experienced chronic pain with a sudden increase in the intensity of their discomfort. A dog with bone cancer that develops a sudden fracture, or a patient with a chronic knee injury followed by a full tear of a ligament are examples of such pain.
http://www.aztecanimalclinic.com/painmgt.htm
Acute on chronic pain. Acute pain may arise on a background of chronic pain, for example due to .....
http://www.mhra.gov.uk/home/idcplg?IdcService=GET_FILE&dDocN...
Types of Pain
Pain in the veterinary patient can be divided into two general catagories -- acute and chronic pain -- with a third category that combines the two: acute on chronic.
Acute Pain. This is the pain generated by a traumatic or medical event that happens suddenly in an otherwise pain-free patient. Examples of events that can cause acute pain are surgical procedures, automobile accidents and other traumatic accidents, and medical conditions such as inflammation of the pancreas.
Chronic Pain. Chronic pain is often caused by conditions such as arthritis or chronic intervertebral disc disease. This is a very common category of pain in our patients.
Acute on Chronic. Occasionally we will see patients that have experienced chronic pain with a sudden increase in the intensity of their discomfort. A dog with bone cancer that develops a sudden fracture, or a patient with a chronic knee injury followed by a full tear of a ligament are examples of such pain.
http://www.aztecanimalclinic.com/painmgt.htm
Discussion